Security and immunogenicity of Fc-EDA, a recombinant ectodysplasin A1 alternative protein, in human topics.
In X-linked hypohidrotic ectodermal dysplasia (XLHED), essentially the most frequent ectodermal dysplasia, an inherited deficiency of the signaling protein ectodysplasin A1 (EDA1) impairs the
improvement of the pores and skin and its appendages, numerous eccrine glands, and dentition.
The extreme hypohidrosis frequent to XLHED sufferers could result in life-threatening hyperthermia, particularly throughout scorching climate or febrile sickness. Fc-EDA, an EDA1 alternative protein recognized to forestall the illness in new child animals, was examined in two scientific trials (human adults and neonates) and moreover administered beneath compassionate use to 3 infants in utero. The information help the protection of Fc-EDA and efficacy if utilized prenatally.
Anti-drug antibodies have been detected after intravenous administration in grownup males and non-pregnant females, however not in pregnant girls when Fc-EDA was delivered intra-amniotically. Most significantly, there was no detectable immune response to the investigational drug in neonates handled by intravenous infusions and in infants who had acquired Fc-EDA in utero. In conclusion, the protection profile of this drug encourages additional improvement of prenatal EDA1 alternative remedy.
Recombinant Human CD40 Ligand/CD40L/TNFSF5
|
Description: Lyophilized from a 0.2 μm filtered resolution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0.
|
|
The efficacy and security of recombinant human soluble thrombomodulin (rhsTM) haven’t been positively confirmed. The consequences could depend upon the presence of sepsis-associated coagulopathy (SAC).

stat-2
The purpose of this systematic evaluation and meta-analysis was to guage the efficacy and security of rhsTM in sufferers with SAC outlined by excessive worldwide normalized ratio and low platelet depend.EMBASE, MEDLINE, CENTRAL and clinicaltrial.gov have been looked for randomized managed trials (RCTs) evaluating rhsTM with placebo or no remedy in sufferers with sepsis.
The efficacy end result was 28-day mortality, and the protection end result was main bleeding. We included three RCTs with a complete of 1,633 sufferers. 28-day mortality was greater in sufferers with SAC in contrast with these with out SAC (threat ratio [RR] 1.32; 95% confidence intervals [CI], 1.06-1.64).
rhsTM was related to considerably decrease 28-day mortality in contrast with placebo or no remedy in sufferers with SAC (RR 0.80; 95% CI, 0.65-0.98), however not in these with out SAC (RR 1.17; 95% CI, 0.82-1.67) nor in the entire examine inhabitants (RR 0.88; 95% CI, 0.74-1.04).
There was no vital distinction in main bleeding between rhsTM and controls in the entire inhabitants (RR 1.25; 95% CI, 0.80-1.96), sufferers with SAC (RR 0.94; 95% CI, 0.45-1.95), and people with out SAC (RR 2.26; 95% CI, 0.95-5.35).In sufferers with sepsis, SAC is related to greater 28-day mortality.
The administration of rhsTM diminished 28-day mortality in sufferers with SAC, however not in these with out SAC.
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, Untagged, E.coli-100ug
|
In evaluating new medicine for the remedy of assorted kinds of most cancers, investigations have been made to find a wide range of anti-tumor compounds with much less unwanted effects on regular cells.
Investigations have proven that the heterodimers S100A8 and S100A9 inhibit the enzyme casein kinase 2 after which prevents the activation of the E7 oncoprotein. Subsequently, the purpose of this examine was to guage the impact of calprotectinas antitumor compound on the Nalm6 (B cell precursor leukemia cell line). Transformation of genes encoding S100Aeight and S100A9 human, designed within the pQE32 plasmid, was carried out by thermal shock technique into E. coli M15 micro organism.
After bacterial progress in LB medium, the expression of two S100A8 and S100A9 subunits the solubility of the protein by SDS-PAGE technique was decided. Lastly, the S100A8 / A9 complicated was equally positioned within the microtube.
Within the subsequent step, the cytotoxic results of calprotectin produced on the Nalm6 cell line have been evaluated utilizing the wst1 check. Then, the apoptosis in these cells was measured utilizing stream cytometry strategies with Annexin-V coloration.
Within the present examine the outcomes confirmed that cytotoxic results of Calprotectin is time and focus dependent. So, it could actually cut back the tumor expression and had helpful impact by induced apoptosis in Nalm6 cell line.Calprotectin has anti-tumor impact on Nalm6 cell line by rising apoptosis.
CD154/CD40L/TNFSF5 |
E21-I56 |
EnoGene |
10ug |
EUR 343.00 |
Polyclonal Goat anti-GST α-form |
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 280.00 |
Polyclonal Goat anti-GST μ-form |
GST-ANTI-2 |
Detroit R&D |
50 uL |
EUR 280.00 |
Polyclonal Goat anti-GST p-form |
GST-ANTI-3 |
Detroit R&D |
50 uL |
EUR 280.00 |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 |
CI56-10ug |
Novoprotein |
10ug |
EUR 146.00 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 |
CI56-1mg |
Novoprotein |
1mg |
EUR 2283.00 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 |
CI56-500ug |
Novoprotein |
500ug |
EUR 1613.00 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 |
CI56-50ug |
Novoprotein |
50ug |
EUR 303.00 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Human CellExp? CD40 Ligand / TNFSF5, Human Recombinant |
P1174-10 |
Biovision |
|
EUR 164.00 |
Human CellExp? CD40 Ligand / TNFSF5, Human Recombinant |
P1174-50 |
Biovision |
|
EUR 555.00 |
CD40LG/TNFSF5 (Cd40 Ligand) Antibody |
20-abx111483 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
Recombinant Human CD40 Ligand/CD40L/TNFSF5 (E. coli) |
C011-10ug |
Novoprotein |
10ug |
EUR 100.00 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 (E. coli) |
C011-1mg |
Novoprotein |
1mg |
EUR 943.00 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 (E. coli) |
C011-500ug |
Novoprotein |
500ug |
EUR 674.00 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Recombinant Human CD40 Ligand/CD40L/TNFSF5 (E. coli) |
C011-50ug |
Novoprotein |
50ug |
EUR 192.00 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 200mM NaCl, 0.1mM EDTA, pH 7.0. |
Human CellExp? CD40 Ligand / TNFSF5, Fc tag, Human Recombinant |
P1175-10 |
Biovision |
|
EUR 164.00 |
Human CellExp? CD40 Ligand / TNFSF5, Fc tag, Human Recombinant |
P1175-50 |
Biovision |
|
EUR 555.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, Untagged, E.coli-100ug |
QP10359-ec-100ug |
EnQuireBio |
100ug |
EUR 525.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, Untagged, E.coli-10ug |
QP10359-ec-10ug |
EnQuireBio |
10ug |
EUR 154.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, Untagged, E.coli-250ug |
QP10359-ec-250ug |
EnQuireBio |
250ug |
EUR 898.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, Untagged, E.coli-50ug |
QP10359-ec-50ug |
EnQuireBio |
50ug |
EUR 290.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, Untagged, E.coli-1mg |
QP5332-1mg |
EnQuireBio |
1mg |
EUR 1361.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, Untagged, E.coli-500ug |
QP5332-500ug |
EnQuireBio |
500ug |
EUR 826.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, GST, E.coli-100ug |
QP8528-ec-100ug |
EnQuireBio |
100ug |
EUR 408.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, GST, E.coli-10ug |
QP8528-ec-10ug |
EnQuireBio |
10ug |
EUR 200.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, GST, E.coli-1mg |
QP8528-ec-1mg |
EnQuireBio |
1mg |
EUR 1632.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, GST, E.coli-200ug |
QP8528-ec-200ug |
EnQuireBio |
200ug |
EUR 634.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, GST, E.coli-500ug |
QP8528-ec-500ug |
EnQuireBio |
500ug |
EUR 1060.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, GST, E.coli-50ug |
QP8528-ec-50ug |
EnQuireBio |
50ug |
EUR 263.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, His, Yeast-100ug |
QP9047-ye-100ug |
EnQuireBio |
100ug |
EUR 480.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, His, Yeast-10ug |
QP9047-ye-10ug |
EnQuireBio |
10ug |
EUR 236.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, His, Yeast-1mg |
QP9047-ye-1mg |
EnQuireBio |
1mg |
EUR 1885.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, His, Yeast-200ug |
QP9047-ye-200ug |
EnQuireBio |
200ug |
EUR 744.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, His, Yeast-500ug |
QP9047-ye-500ug |
EnQuireBio |
500ug |
EUR 1206.00 |
Recombinant Human CD40L/ CD154/ TNFSF5 Protein, His, Yeast-50ug |
QP9047-ye-50ug |
EnQuireBio |
50ug |
EUR 299.00 |
Human Monokine Induced By Interferon Gamma (MIg) ELISA Equipment
|
Automated patch clamp (APC) devices allow environment friendly analysis of electrophysiologic results of medicine on human cardiac currents in heterologous expression methods.
Variations in experimental protocols, devices, and dissimilar web site procedures have an effect on the variability of IC50 values characterizing drug block efficiency. This impacts the utility of APC platforms for assessing a drug’s cardiac security margin.
We decided variability of APC knowledge from a number of websites that measured blocking efficiency of 12 blinded medicine (with totally different ranges of proarrhythmic threat) towards 4 human cardiac currents (hERG [IKr], hCav1.2 [L-Type ICa], peak hNav1.5, [Peak INa], late hNav1.5 [Late INa]) with really useful protocols (to reduce variance) utilizing 5 APC platforms throughout 17 websites. IC50 variability (25/75 percentiles) differed for medicine and currents (e.g., 10.4-fold for dofetilide block of hERG present and 4-fold for mexiletine block of hNav1.5 present).
Inside-platform variance predominated for Four of 12 hERG blocking medicine and Four of 6 hNav1.5 blocking medicine. hERG and hNav1.5 block. Bland-Altman plots depicted various settlement throughout APC platforms.
A follow-up survey recommended a number of sources of experimental variability that may very well be additional minimized by stricter adherence to plain protocols. Adoption of greatest practices would guarantee much less variable APC datasets and improved security margins and proarrhythmic threat assessments.
Human Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
RDR-MIg-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 331.00 |
Human Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
RDR-MIg-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 451.00 |
Human Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
RD-MIg-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 318.00 |
Human Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
RD-MIg-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 432.00 |
anti- MIG antibody |
FNab05188 |
FN Test |
100µg |
EUR 505.25 |
- Recommended dilution: WB: 1:500-1:2000
- Immunogen: chemokine(C-X-C motif) ligand 9
- Uniprot ID: Q07325
- Gene ID: 4283
- Research Area: Immunology, Signal Transduction
|
Description: Antibody raised against MIG |
Anti-MIG antibody |
STJ98702 |
St John's Laboratory |
200 µl |
EUR 197.00 |
Description: Rabbit polyclonal to MIG. |
Anti-MIG (1F5) |
YF-MA14255 |
Abfrontier |
100 ug |
EUR 363.00 |
Description: Mouse monoclonal to MIG |
Mouse Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
DLR-MIg-Mu-48T |
DL Develop |
48T |
EUR 454.00 |
- Should the Mouse Monokine Induced By Interferon Gamma (MIg) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Monokine Induced By Interferon Gamma (MIg) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
DLR-MIg-Mu-96T |
DL Develop |
96T |
EUR 587.00 |
- Should the Mouse Monokine Induced By Interferon Gamma (MIg) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Monokine Induced By Interferon Gamma (MIg) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rat Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
DLR-MIg-Ra-48T |
DL Develop |
48T |
EUR 475.00 |
- Should the Rat Monokine Induced By Interferon Gamma (MIg) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
Description: A sandwich quantitative ELISA assay kit for detection of Rat Monokine Induced By Interferon Gamma (MIg) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Rat Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
DLR-MIg-Ra-96T |
DL Develop |
96T |
EUR 616.00 |
- Should the Rat Monokine Induced By Interferon Gamma (MIg) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
|
Description: A sandwich quantitative ELISA assay kit for detection of Rat Monokine Induced By Interferon Gamma (MIg) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Mouse Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
RDR-MIg-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 470.00 |
Mouse Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
RDR-MIg-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 651.00 |
Rat Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
RDR-MIg-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 495.00 |
Rat Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
RDR-MIg-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 685.00 |
Mouse Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
RD-MIg-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 450.00 |
Mouse Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
RD-MIg-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 622.00 |
Rat Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
RD-MIg-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 473.00 |
Rat Monokine Induced By Interferon Gamma (MIg) ELISA Kit |
RD-MIg-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 655.00 |
Rabbit Polyclonal antibody Anti-CRBN |
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 349.00 |
Anti-MIG/CXCL9 Antibody |
PA1429 |
BosterBio |
100ug/vial |
EUR 334.00 |
Anti-MIG/CXCL9 Antibody |
PB9694 |
BosterBio |
100ug/vial |
EUR 294.00 |
anti-Mig-6 (clone 4) |
AR18-MA0001 |
Abfrontier |
100 ul |
EUR 334.00 |
Description: Mouse monoclonal to Mig-6 |
MIG, human recombinant |
4240-1000 |
Biovision |
|
EUR 4563.00 |
MIG, human recombinant |
4240-20 |
Biovision |
|
EUR 289.00 |
MIG, CXCL9, human |
RC312-20 |
Bio Basic |
5ug |
EUR 104.38 |
- Product category: Proteins/Recombinant Proteins/Cytokines
|
Armenian Hamster Anti-Mouse CXCL9 (MIG) Monoclonal antibody, clone MIG-2F5.5 |
CABT-L4535-1mg |
Creative Diagnostics |
1 mg |
EUR 897.00 |
Armenian Hamster Anti-Mouse CXCL9 (MIG) Monoclonal antibody, clone MIG-2F5.5 |
CABT-L4535-5mg |
Creative Diagnostics |
5 mg |
EUR 2405.00 |
MIG protein |
30R-2543 |
Fitzgerald |
20 ug |
EUR 358.00 |
Description: Purified recombinant Human MIG protein |
MIG protein |
30R-2544 |
Fitzgerald |
20 ug |
EUR 358.00 |
Description: Purified recombinant Mouse MIG protein |
MIG protein |
30R-AM013 |
Fitzgerald |
20 ug |
EUR 273.00 |
Description: Purified recombinant Human MIG protein |
MIG antibody |
10R-M169A |
Fitzgerald |
500 ug |
EUR 273.00 |
Description: Mouse monoclonal MIG antibody |
MIG antibody |
70R-MR007 |
Fitzgerald |
50 ug |
EUR 327.00 |
Description: Affinity purified Rabbit polyclonal MIG antibody |
Mouse Anti-Insulin IgG ELISA Kit, 96 tests, Quantitative |
3700-MIG |
Alpha Diagnostics |
1 Kit |
EUR 773.00 |
Recombinant Human MIG (CXCL9) |
7-02002 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human MIG (CXCL9) |
7-02003 |
CHI Scientific |
20µg |
Ask for price |
Recombinant Human MIG (CXCL9) |
7-02004 |
CHI Scientific |
1mg |
Ask for price |
Polyclonal Goat anti-GST α-form |
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 280.00 |
Polyclonal Goat anti-GST μ-form |
GST-ANTI-2 |
Detroit R&D |
50 uL |
EUR 280.00 |
Polyclonal Goat anti-GST p-form |
GST-ANTI-3 |
Detroit R&D |
50 uL |
EUR 280.00 |
MIG protein (Mouse) |
30R-AM014 |
Fitzgerald |
20 ug |
EUR 273.00 |
Description: Purified recombinant Mouse MIG protein |
MIG Polyclonal Antibody |
46885-100ul |
SAB |
100ul |
EUR 252.00 |
MIG Polyclonal Antibody |
46885-50ul |
SAB |
50ul |
EUR 187.00 |
MIG, murine recombinant |
4241-1000 |
Biovision |
|
EUR 4345.00 |